At least 130 Palestinians were hit by Israeli gunfire as thousands protested near Gaza's border with Israel, the health ministry in the enclave said.
Following calls to avoid an escalation in violence, the demonstrators largely kept their distance from the fortified frontier fence.
But at least 130 Palestinians were injured on Friday by live fire in clashes with Israeli soldiers, the health ministry said.
An Israeli army spokesman told Agence France-Presse that while most of the protesters stayed back from the fence, some came close and threw explosive devices and hand grenades at troops, while burning tyres.
"The soldiers who were there responded with riot dispersal means, along with gunfire in accordance with the rules of engagement," he said.
Rockets fired from Gaza on Wednesday had brought the territory's Hamas rulers and Israel closer to a widescale confrontation.
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Since March, Palestinians have moved right up to the border fence every Friday and occasionally breached it, leading to clashes in which more than 200 Palestinians and one Israeli have been killed.
While thousands again gathered for the latest protests in northern Gaza, the demonstrators largely remained at least 100 metres from the border.
An Agence France-Presse correspondent said Hamas security officials in at least one location were seen discouraging protesters from nearing the fence.
Kites and balloons equipped with incendiary devices were launched across the border into southern Israel, and the Israeli army said one of its aircraft targeted a group of men launching balloons.
An Egyptian security delegation visited the Gaza Strip on Thursday and encouraged Hamas leader Ismail Haniya to calm the protests, an Egyptian official said.
United Nations envoy Nickolay Mladenov, in a tweet, also urged all sides "to exercise restraint, to proceed in a peaceful manner, and to avoid escalation".
On Wednesday, two rockets were fired from the Palestinian enclave at Israel, with one destroying a house in the southern city of Beersheba.
In response Israeli air strikes targeted around 20 Hamas targets in Gaza.
TRAP
Starring: Josh Hartnett, Saleka Shyamalan, Ariel Donaghue
Director: M Night Shyamalan
Rating: 3/5
BORDERLANDS
Starring: Cate Blanchett, Kevin Hart, Jamie Lee Curtis
Director: Eli Roth
Rating: 0/5
LEAGUE CUP QUARTER-FINAL DRAW
Stoke City v Tottenham
Brentford v Newcastle United
Arsenal v Manchester City
Everton v Manchester United
All ties are to be played the week commencing December 21.
How to protect yourself when air quality drops
Install an air filter in your home.
Close your windows and turn on the AC.
Shower or bath after being outside.
Wear a face mask.
Stay indoors when conditions are particularly poor.
If driving, turn your engine off when stationary.
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Israel Palestine on Swedish TV 1958-1989
Director: Goran Hugo Olsson
Rating: 5/5
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Greatest of All Time
Starring: Vijay, Sneha, Prashanth, Prabhu Deva, Mohan
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THE BIO
Born: Mukalla, Yemen, 1979
Education: UAE University, Al Ain
Family: Married with two daughters: Asayel, 7, and Sara, 6
Favourite piece of music: Horse Dance by Naseer Shamma
Favourite book: Science and geology
Favourite place to travel to: Washington DC
Best advice you’ve ever been given: If you have a dream, you have to believe it, then you will see it.
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