Aaron Rodgers tossed three touchdown passes and Michael Vick was intercepted in the end zone late in the game as Green Bay held on to beat Philadelphia 21-16 in the first round of the NFL play-offs.
Tramon Williams sealed the victory by intercepting Eagles quarterback Vick's pass to Riley Cooper in the end zone with 33 seconds remaining.
Joe Flacco threw two touchdowns and passed for 265 yards as the Baltimore Ravens forced five turnovers en route to a 30-7 win over Kansas City in the early game on Sunday.
Eagles kicker David Akers missed two field goal attempts while Vick finished with 292 yards passing and ran one touchdown in for a score.
But the Packers' defence did a good job stopping Vick, preventing him from making the game-breaking plays he is known for.
"It's a bad way to go out, but hey, I went out swinging," Vick said.
The Eagles' loss means an end to another tumultuous season for Vick who is in his second year in Philadelphia but first as the starting quarterback - a role he took over halfway through the season. He started the year as the backup after serving 21 months in prison for his role in a brutal dog-fighting ring.
Vick, who recently said he wants to own a dog again, received some unusual support last month from the US president Barack Obama who said Vick has served his time in jail and deserves another chance.
Vick also received a gift from National Basketball Association star Kobe Bryant in the form of an autographed jersey with the words "Be Epic" written on it.
Things could not have been smoother for Vick's quarterback counterpart Rodgers, who once served as a backup to Brett Favre.
Rodgers picked up his first play-off win on Sunday in just his second try.
"I never felt like there was a monkey on my back," Rodgers said. "I'm just so proud of these guys. We fought hard today. Big interception by Tramon who's had a great season for us."
The sixth-seeded Packers now head to Atlanta for a second-round play-off game next Saturday.
The Ravens broke open a tight game in the third quarter with two field goals off three turnovers to set up a play-off contest against the Pittsburgh Steelers also on Saturday.
It will mark the third time this season the Steelers and Ravens have squared off.
"We'd be happy to see them (Pittsburgh) out of it," Ravens head coach John Harbaugh said. "But it seems like it's poetic justice."
Harbaugh gave the game ball to Baltimore player Ed Reed, whose brother, Brian, is still missing after leaping into the Mississippi River on Friday while being chased by police.
Ray Rice, Anquan Boldin and Willis McGahee all scored touchdowns for Baltimore which went on a 27-point unanswered run at one point in Sunday's AFC wild card game.
"We were able to keep going," said Flacco. "It was a really good team victory."
Kansas City now has the dubious distinction of owning the longest playoff winless streak at seven consecutive games. The Chiefs, who won the AFC West this season, have gone 17 years since their last post-season win.
Flacco completed 25 of 34 passes, including a nine-yard touchdown pass to Rice in the second quarter that gave Baltimore a lead they would never relinquish.
Flacco's four-yard scoring pass to Boldin with 32 seconds left in the third quarter gave Baltimore a commanding 23-7 lead.
Ravens' Dawan Landry picked off a pass by Kansas City quarterback Matt Cassel to set up Baltimore at the Chiefs' 31 yard line earlier in the quarter.
"We turned the ball over and that's not characteristic of us," Kansas City all star guard Brian Waters said.
"When we had to make plays, we weren't able to. When they had to make plays, they did. You can't turn the ball over."