Tottenham v Chelsea (midnight): It's all going wrong for Jose Mourinho and Spurs. Losing talisman striker Harry Kane to injury was always going to be a major problem and successive defeats against Liverpool and Brighton have seen Spurs drop out of the top five. "We are in a difficult moment," admitted their Portuguese manager. Thomas Tuchel is up and running at Chelsea as the German secured his first win as new Blues manager by beating Burnley 2-0 on Sunday. Two players recalled to their starting line-up - Cesar Azpilicueta and Marcos Alonso - scored the goals. Prediction: Tottenham 1 Chelsea 3. AFP
Sheffield United v West Bromwich Albion (10pm kick-off UAE): Battle of the bottom two at Bramall Lane with both sides desperate for three points in their fight to avoid the drop. Sheffield United already need a miracle to stay up, sitting 13 points off safety, while West Brom are hefty nine away from escaping the bottom three. Sam Allardyce has signed striker striker Mbaye Diagne - "a big man from Galatasaray" - on loan so it's safe to say you can expect a direct approach from the Baggies from here on in. Prediction: Sheffield United 1 West Brom 1. AFP
Wolves v Arsenal (10pm): Testing times for Nuno Espirito Santo. After successive top-seven finishes, the Wolves manager has seen his team drop to 14th in the table this campaign, without a win in eight. Nuno said following their latest defeat, at Crystal Palace, that he has "a lot of concerns" about their form and that Wolves "must improve fast". The Gunners will be a tough nut to crack here; undefeated in the Premier League since December 19 and having conceded just one goal in the whole of January. Prediction: Wolves 0 Arsenal 2. Getty
WEDNESDAY: Manchester United v Southampton (12.15am): A big game for United as they look to regain momentum in the title chase. A shock home defeat by rock-bottom Sheffield United was followed up by a goalless draw at Arsenal and Red Devils manager Ole Gunnar Solskjaer needs to get his attacking unit firing again. Southampton have slumped to three defeats on the spin and dropped out of the top half of the table. Prediction: United 2 Southampton 1. EPA
Newcastle United v Crystal Palace (12.15am): Immense relief for under pressure Newcastle manager Steve Bruce as his team ended a 12-game stretch without a win by beating Everton 2-0. The win also stopped a five-game losing run, while Callum Wilson ended a seven-match goal drought by scoring both goals at Goodison Park. "There's no disputing it - it's been very difficult," Bruce said with some understatement. Palace's win against against Wolves last time out meant they avoided a third defeat on the trot themselves. Prediction: Newcastle 1 Palace 0. EPA
Burnley v Manchester City (10pm): Momentum is certainly with Manchester City at the moment. A club-record 12th successive victory was sealed by their 1-0 win over Sheffield United on Saturday. And Pep Guardiola's side have now kept five clean sheets in a row in the Premier League, and 11 out of their last 13. Burnley dragged themselves away from the drop zone with wins against Liverpool and Aston Villa in January but were comprehensively beaten by Chelsea last time out. Prediction: Burnley 0 City 2. AFP
Fulham v Leicester (10pm): Fulham manager Scott Parker did not hide his frustration when his team could only draw 2-2 at fellow relegation strugglers West Brom on Saturday. "The game should have been out of sight at half time," fumed Parker. The Cottagers are third bottom, seven points shy of safety. Leicester manager Brendan Rodgers had his own problems 24 hours later when his team were dispatched 3-1 by Leeds. A win would have seen the Foxes move just two points behind league leaders Manchester City. Prediction: Fulham 1 Leicester 2. Reuters
Leeds United v Everton (11.30pm): Contrasting fortunes for these two clubs last time out. Leeds sealed a superb 3-1 win at high-flying Leicester - with Patrick Bamford scoring one and setting up the other two. Everton, on the other hand, slumped to a miserable 2-0 home defeat against Newcastle that left manager Carlo Ancelotti admitting: "We were lazy, we were slow, we were not focused." Prediction: Leeds 2 Everton 2. AFP
THURSDAY - Aston Villa v West Ham (12.15am): An interesting clash between two teams that struggled last season, but have hopes of securing European football this campaign. Villa currently sit ninth in the table, three points and four places behind the Hammers and will jump ahead of their opponents on goal difference if they win here. Prediction: Villa 1 West Ham 2. Reuters
Liverpool v Brighton (12.15am): Mohamed Salah was back with a bang for Liverpool on Sunday, scoring for the first time in seven Premier League games with a brilliant double in their 3-1 win West Ham. And that came on the back of their dismantling of Tottenham by the same scoreline. Brighton enjoyed what manager Graham Potter called "our best performance" in two seasons when they also defeated Spurs, with a thoroughly deserved 1-0 win on the south coast. Prediction: Liverpool 3 Brighton 0. AFP
Tottenham v Chelsea (midnight): It's all going wrong for Jose Mourinho and Spurs. Losing talisman striker Harry Kane to injury was always going to be a major problem and successive defeats against Liverpool and Brighton have seen Spurs drop out of the top five. "We are in a difficult moment," admitted their Portuguese manager. Thomas Tuchel is up and running at Chelsea as the German secured his first win as new Blues manager by beating Burnley 2-0 on Sunday. Two players recalled to their starting line-up - Cesar Azpilicueta and Marcos Alonso - scored the goals. Prediction: Tottenham 1 Chelsea 3. AFP
Sheffield United v West Bromwich Albion (10pm kick-off UAE): Battle of the bottom two at Bramall Lane with both sides desperate for three points in their fight to avoid the drop. Sheffield United already need a miracle to stay up, sitting 13 points off safety, while West Brom are hefty nine away from escaping the bottom three. Sam Allardyce has signed striker striker Mbaye Diagne - "a big man from Galatasaray" - on loan so it's safe to say you can expect a direct approach from the Baggies from here on in. Prediction: Sheffield United 1 West Brom 1. AFP
Wolves v Arsenal (10pm): Testing times for Nuno Espirito Santo. After successive top-seven finishes, the Wolves manager has seen his team drop to 14th in the table this campaign, without a win in eight. Nuno said following their latest defeat, at Crystal Palace, that he has "a lot of concerns" about their form and that Wolves "must improve fast". The Gunners will be a tough nut to crack here; undefeated in the Premier League since December 19 and having conceded just one goal in the whole of January. Prediction: Wolves 0 Arsenal 2. Getty
WEDNESDAY: Manchester United v Southampton (12.15am): A big game for United as they look to regain momentum in the title chase. A shock home defeat by rock-bottom Sheffield United was followed up by a goalless draw at Arsenal and Red Devils manager Ole Gunnar Solskjaer needs to get his attacking unit firing again. Southampton have slumped to three defeats on the spin and dropped out of the top half of the table. Prediction: United 2 Southampton 1. EPA
Newcastle United v Crystal Palace (12.15am): Immense relief for under pressure Newcastle manager Steve Bruce as his team ended a 12-game stretch without a win by beating Everton 2-0. The win also stopped a five-game losing run, while Callum Wilson ended a seven-match goal drought by scoring both goals at Goodison Park. "There's no disputing it - it's been very difficult," Bruce said with some understatement. Palace's win against against Wolves last time out meant they avoided a third defeat on the trot themselves. Prediction: Newcastle 1 Palace 0. EPA
Burnley v Manchester City (10pm): Momentum is certainly with Manchester City at the moment. A club-record 12th successive victory was sealed by their 1-0 win over Sheffield United on Saturday. And Pep Guardiola's side have now kept five clean sheets in a row in the Premier League, and 11 out of their last 13. Burnley dragged themselves away from the drop zone with wins against Liverpool and Aston Villa in January but were comprehensively beaten by Chelsea last time out. Prediction: Burnley 0 City 2. AFP
Fulham v Leicester (10pm): Fulham manager Scott Parker did not hide his frustration when his team could only draw 2-2 at fellow relegation strugglers West Brom on Saturday. "The game should have been out of sight at half time," fumed Parker. The Cottagers are third bottom, seven points shy of safety. Leicester manager Brendan Rodgers had his own problems 24 hours later when his team were dispatched 3-1 by Leeds. A win would have seen the Foxes move just two points behind league leaders Manchester City. Prediction: Fulham 1 Leicester 2. Reuters
Leeds United v Everton (11.30pm): Contrasting fortunes for these two clubs last time out. Leeds sealed a superb 3-1 win at high-flying Leicester - with Patrick Bamford scoring one and setting up the other two. Everton, on the other hand, slumped to a miserable 2-0 home defeat against Newcastle that left manager Carlo Ancelotti admitting: "We were lazy, we were slow, we were not focused." Prediction: Leeds 2 Everton 2. AFP
THURSDAY - Aston Villa v West Ham (12.15am): An interesting clash between two teams that struggled last season, but have hopes of securing European football this campaign. Villa currently sit ninth in the table, three points and four places behind the Hammers and will jump ahead of their opponents on goal difference if they win here. Prediction: Villa 1 West Ham 2. Reuters
Liverpool v Brighton (12.15am): Mohamed Salah was back with a bang for Liverpool on Sunday, scoring for the first time in seven Premier League games with a brilliant double in their 3-1 win West Ham. And that came on the back of their dismantling of Tottenham by the same scoreline. Brighton enjoyed what manager Graham Potter called "our best performance" in two seasons when they also defeated Spurs, with a thoroughly deserved 1-0 win on the south coast. Prediction: Liverpool 3 Brighton 0. AFP
Tottenham v Chelsea (midnight): It's all going wrong for Jose Mourinho and Spurs. Losing talisman striker Harry Kane to injury was always going to be a major problem and successive defeats against Liverpool and Brighton have seen Spurs drop out of the top five. "We are in a difficult moment," admitted their Portuguese manager. Thomas Tuchel is up and running at Chelsea as the German secured his first win as new Blues manager by beating Burnley 2-0 on Sunday. Two players recalled to their starting line-up - Cesar Azpilicueta and Marcos Alonso - scored the goals. Prediction: Tottenham 1 Chelsea 3. AFP