Manchester United fall at Manchester City, Chelsea extend impressive run: Premier League predictions

We pick out the winners and losers from the latest round of fixtures

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  SATURDAY: Burnley v Arsenal (4.30pm) - Four games without a win means Burnley are start to look over their shoulders in the Premier League table. Arsenal sit in tenth. but have found where the goal is of late. Prediction: Burnley 0 Arsenal 2. AP

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  Sheffield United v Southampton (7pm) - A welcome win for Sheffield United against Aston Villa last time out while the Saints have been struggling. Surely too big an ask for the Blades to escape relegation, but perhaps more points here. Prediction: Sheffield United 1 Southampton 0. AP

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  Aston Villa v Wolves, 9.30pm - Villa coach Dean Smith says captain Jack Grealish "looks pain-free" but is unlikely to make his comeback from a shin problem. That's bad news for Villa. Prediction: Aston Villa 0 Wolves 2. PA

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  Brighton v Leicester (midnight) - Leicester have already beaten Brighton twice this season, in the Premier League and FA Cup. But they face a big battle here as they try and cling on to a top four spot. Prediction: Brighton 1 Leicester 1. AFP

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  SUNDAY: West Bromwich Albion v Newcastle United (4pm) - Newcastle are in a right mess. Manager Steve Bruce has seemingly fallen out with his players, and they have suffered eight defeats in 2021, a joint league-high along with Southampton. Plus lots of injuries. Prediction: West Brom 1 Newcastle 0. PA

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  Liverpool v Fulham (6pm) - Until the turn of the year this would have been a formality, but such is Liverpool's dire form, nothing can be taken for granted any longer. Fulham are fighting for their lives, and will be hopeful of causing another upset. Prediction: Liverpool 1 Fulham 1. Getty

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  Manchester City v Manchester United (8.30pm) - The pick of the fixtures. City are breaking records in their 20-game winning streak, and if anything are getting better by the week. United have forgotten how to score goals, but will not give this one up without a fight. Prediction: Manchester City 2 Manchester United 1. EPA

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  Tottenham Hotspur v Crystal Palace (10.15pm) - With Gareth Bale finding form, and Harry Kane and Son Heung-min alongside him, Spurs should be scoring for fun. Palace have eased away from trouble of late, and that might work to Tottenham's advantage. Prediction: Tottenham 3 Crystal Palace 1. Reuters

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  MONDAY: Chelsea v Everton (10pm) - Thomas Tuchel has already proved what a great manager he is, with Chelsea unbeaten in 10 games in all competitions since he replaced Frank Lampard in January. The Blues are one point clear of fifth placed Everton - but they haven't lost away since November 1. Prediction: Chelsea 2 Everton 1. Getty

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  West Ham United v Leeds United (midnight) - West Ham's fine form - defeat against Manchester City can be excused - has seen them challenge for a place in the top four. Leeds are maddeningly inconsistent, and might struggle here. Prediction: West Ham 2 Leeds 0. Getty

The Premier League continues at breakneck speed, and the Manchester derby provides the pick of the action this round.

The matches get underway on Saturday with Arsenal's trip to Burnley, followed by bottom-of-the-table Sheffield United hosting Southampton, Aston Villa against Wolves, and the late one is Brighton against Leicester.

Sunday starts with West Brom against struggling Newcastle, then Liverpool attempt to get back to winning ways when they host Fulham. The big game follows, as Manchester City attempt to extend their winning run to 22 when they take on Manchester United. The day wraps up with Tottenham against Crystal Palace.

Chelsea are first up on Monday when Thomas Tuchel attempts to extend his unbeaten record against Everton, then West Ham host Leeds United.

Predictions for the games are in the photo gallery above. To move on to the next photo, click on the arrows, or if using a mobile device simply