Tottenham v Leeds (8.30pm): Harry Kane has been banging in goals during the international break for England - now Spurs need him to transfer that scoring touch into a league campaign that has seen the striker find the target just once. Leeds' form continues to be erratic and this looks good for a Kane goal and Tottenham win. Prediction: Spurs 2 Leeds 1. PA
SATURDAY - Leicester v Chelsea (4.30pm): Table-toppers Chelsea will be aiming for a return to winning ways after drawing at home to Burnley before the international break. Leicester, while still searching for some consistency in what has been an injury-hit campaign so far, are more than capable of frustrating Tuchel's side again here. Prediction: Leicester 2 Chelsea 2. Reuters
Aston Villa v Brighton (7pm): The Steven Gerrard era begins with the new Villa manager looking to end the team's miserable run of five defeats in a row. Brighton are a tough nut to crack this season, although the Seagulls are now without a win in six - having drawn five and losing one of those games. Prediction: Villa 3 Brighton 1. Reuters
Burnley v Crystal Palace (7pm): Patrick Vieira's Eagles are flying after finally turning draws into victories, while only suffering two defeats all season. Only Chelsea and Liverpool have lost fewer games. Burnley have taken five points from the last nine on offer but remain in the relegation zone. Prediction: Burnley 0 Palace 1. Reuters
Newcastle v Brentford (7pm): Eddie Howe also starts his managerial reign with a home game, where the St James' Park crowd will be urging on Newcastle to seal their first win of the season at the 12th attempt. Brentford have lost four in a row and the Magpies need points on the board ahead of a tricky December schedule. Prediction: Newcastle 2 Brentford 0. Getty
Norwich City v Southampton (7pm): Norwich new boy Dean Smith is the third manager in charge of his new team for the first time this weekend, little over a week after being sacked by Aston Villa. But the size of the task in front of him will become clear against a Southampton team that has won three out of its last four games. Prediction: Norwich 1 Southampton 2.
Watford v Manchester United (7pm): Humbling defeats by Leicester, Liverpool and Manchester City mean that Ole Gunnar Solskjaer is very much in line to become the next Premier League manager to be given the boot. United have won just once in six games and will be desperate for three points at Vicarage Road. Prediction: Watford 1 United 3. Getty
Wolves v West Ham (7pm): The Hammers are flying after their win over Liverpool - a fourth victory on the spin that took them up to third in the table, just three points off the top spot. Wolves lost for the first time in six games against Palace last time out and are in good form - but it's West Ham to maintain their hot streak here. Prediction: Wolves 1 West Ham 2.
Liverpool v Arsenal (9.30pm): Match of the weekend sees fourth place play host to fifth at Anfield. Liverpool fell to their first defeat of the season at West Ham in their last match and take on an Arsenal side who have not lost a league game since August. But that run is set to come to an end on Merseyside. Prediction: Liverpool 2 Arsenal 0. Reuters
SUNDAY - Manchester City v Everton (6pm): City will be buzzing after their derby victory stroll against United that helped banish the memory of a shock defeat to Crystal Palace in the previous match. Everton are struggling for form, missing key players through injury and are without a win since September. Prediction: City 3 Everton 0. PA
Tottenham v Leeds (8.30pm): Harry Kane has been banging in goals during the international break for England - now Spurs need him to transfer that scoring touch into a league campaign that has seen the striker find the target just once. Leeds' form continues to be erratic and this looks good for a Kane goal and Tottenham win. Prediction: Spurs 2 Leeds 1. PA
SATURDAY - Leicester v Chelsea (4.30pm): Table-toppers Chelsea will be aiming for a return to winning ways after drawing at home to Burnley before the international break. Leicester, while still searching for some consistency in what has been an injury-hit campaign so far, are more than capable of frustrating Tuchel's side again here. Prediction: Leicester 2 Chelsea 2. Reuters
Aston Villa v Brighton (7pm): The Steven Gerrard era begins with the new Villa manager looking to end the team's miserable run of five defeats in a row. Brighton are a tough nut to crack this season, although the Seagulls are now without a win in six - having drawn five and losing one of those games. Prediction: Villa 3 Brighton 1. Reuters
Burnley v Crystal Palace (7pm): Patrick Vieira's Eagles are flying after finally turning draws into victories, while only suffering two defeats all season. Only Chelsea and Liverpool have lost fewer games. Burnley have taken five points from the last nine on offer but remain in the relegation zone. Prediction: Burnley 0 Palace 1. Reuters
Newcastle v Brentford (7pm): Eddie Howe also starts his managerial reign with a home game, where the St James' Park crowd will be urging on Newcastle to seal their first win of the season at the 12th attempt. Brentford have lost four in a row and the Magpies need points on the board ahead of a tricky December schedule. Prediction: Newcastle 2 Brentford 0. Getty
Norwich City v Southampton (7pm): Norwich new boy Dean Smith is the third manager in charge of his new team for the first time this weekend, little over a week after being sacked by Aston Villa. But the size of the task in front of him will become clear against a Southampton team that has won three out of its last four games. Prediction: Norwich 1 Southampton 2.
Watford v Manchester United (7pm): Humbling defeats by Leicester, Liverpool and Manchester City mean that Ole Gunnar Solskjaer is very much in line to become the next Premier League manager to be given the boot. United have won just once in six games and will be desperate for three points at Vicarage Road. Prediction: Watford 1 United 3. Getty
Wolves v West Ham (7pm): The Hammers are flying after their win over Liverpool - a fourth victory on the spin that took them up to third in the table, just three points off the top spot. Wolves lost for the first time in six games against Palace last time out and are in good form - but it's West Ham to maintain their hot streak here. Prediction: Wolves 1 West Ham 2.
Liverpool v Arsenal (9.30pm): Match of the weekend sees fourth place play host to fifth at Anfield. Liverpool fell to their first defeat of the season at West Ham in their last match and take on an Arsenal side who have not lost a league game since August. But that run is set to come to an end on Merseyside. Prediction: Liverpool 2 Arsenal 0. Reuters
SUNDAY - Manchester City v Everton (6pm): City will be buzzing after their derby victory stroll against United that helped banish the memory of a shock defeat to Crystal Palace in the previous match. Everton are struggling for form, missing key players through injury and are without a win since September. Prediction: City 3 Everton 0. PA
Tottenham v Leeds (8.30pm): Harry Kane has been banging in goals during the international break for England - now Spurs need him to transfer that scoring touch into a league campaign that has seen the striker find the target just once. Leeds' form continues to be erratic and this looks good for a Kane goal and Tottenham win. Prediction: Spurs 2 Leeds 1. PA
