US pharmaceutical and biotech company <a href="https://www.thenationalnews.com/world/us-news/2022/04/28/moderna-seeks-covid-vaccine-authorisation-for-us-babies-and-children-under-5/" target="_blank">Moderna</a> said first-quarter net profit tripled as its revenue rose on the back of its Covid-19 vaccine. The Massachusetts-based company's net income climbed to about $3.7 billion in the three months to the end of March from $1.2bn in the same period a year earlier, it said in a <a href="https://investors.modernatx.com/news/news-details/2022/Moderna-Reports-First-Quarter-2022-Financial-Results-and-Provides-Business-Updates/default.aspx">statement</a>. Moderna's share price rallied about 6 per cent to $155.05 at the close of trading on Wednesday. Total revenue reached $6.1bn in the January-March period, compared to $1.9 billion for the same period in 2021. The amount included $5.9bn from sales of the company's Covid-19 vaccine, compared with $1.7bn in the first quarter of 2021. Moderna said the prevailing market dynamics will result in Covid-19 vaccine sales “slightly larger in the second half of 2022 than in the first half”. “The Moderna team delivered a strong first-quarter performance and I am thankful for the progress our team continues to make as we advance our pipeline of mRNA medicines. Today, we are reiterating our signed advanced purchase agreements for 2022 of $21bn,” Stephane Bancel, chief executive of Moderna, said. While traditional vaccines give the body a weakened or inactive virus to cause the production of antibodies, mRNA vaccines make cells produce a protein that starts an immune response. The company spent almost $554m on research and development in the first quarter, an increase of more than 38 per cent on an annual basis, mainly due to increases in “personnel-related costs, clinical trial expenses, technology and facility-related costs, and consulting and outside services”, it said. Full-year R&D expenses are expected to be approximately $4bn. Last month, Moderna also submitted a request for an emergency use authorisation in the US for its Covid-19 vaccine for babies aged 6 months to children under 6. Very young children are the only group that are yet to be eligible for the Covid-19 vaccine in the US and in most countries — a source of concern for some parents. In the current quarter ending on June 30, Moderna expects to have four programmes in late-stage phase three studies, including an Omicron-containing bivalent Covid booster candidate, Mr Bancel said. “Beginning in the fall of 2022, our robust phase-three pipeline could lead to three respiratory commercial launches over the next two to three years … mRNA has changed the future of medicine and I look forward to continuing our impact on human health. This is just the beginning,” he added. Cash and cash equivalents stood at $19.3bn as of March 31. Meanwhile, the net cash provided by operating activities was $2.8bn for the three months ended on March 31, compared with $3bn for the same period in 2021. Moderna's earnings per share increased 202 per cent on an annual basis to $8.6 in the first quarter. The company expects total capital investments for 2022 to hover in the range of $600m to $800m. Moderna, which did not conduct share repurchases before the fourth quarter of last year, said it spent $623m in the last quarter for repurchases of common stock. In the last two quarters, the company has repurchased about 7 million shares, reducing the number of common shares outstanding from 405 million to nearly 400 million. In February, the company approved a share repurchase programme for $3bn to return excess capital to shareholders. The previous programme of $1bn, announced in August, was fully utilised as of January 31, the company said.