The Gunners have seen their lead at the top cut to five points after three draws in a row, against Liverpool, West Ham United and Southampton.
City, who have two games in hand on Arsenal, are on a run of six Premier League wins on the spin as well as reaching the Champions League semi-finals and the FA Cup final.
The midweek fixture list starts on Tuesday, though, with Wolves against Crystal Palace at Molineux, Aston Villa play host to Fulham and Leeds United tackling Leicester City in Yorkshire.
Wednesday begins with Nottingham Forest's home game with Brighton, Chelsea face London rivals Brentford at Stamford Bridge, West Ham entertain Liverpool in the capital, before the big game kicks off at the Etihad.
Thursday sees Everton clash with Newcastle United on Merseyside, Southampton up against Bournemouth at St Mary's Stadium and Tottenham Hotspur versus Manchester United at the Tottenham Hotspur Stadium.
Predictions
TUESDAY - Wolves v Crystal Palace (10.30pm kick-off UAE): Both teams have dragged themselves away from the bottom three in recent weeks with Wolves now six points clear of the relegation zone and Palace nine. A disappointing defeat at fellow strugglers Leicester at the weekend, though, has Wolves looking nervously over their shoulders again. Prediction: Wolves 1 Palace 1. Getty
Aston Villa v Fulham (10.45pm): Villa's five-game winning streak was ended with Saturday's draw at Brentford, but manager Unai Emery made clear he was happy with a point, secured thanks to Douglas Luiz's late leveller. They now face a Fulham side looking to make it three wins on the spin. Prediction: Villa 2 Fulham 0. Getty
Leeds v Leicester City (11pm): The relegation six-pointers are coming thick and fast as 16th takes on 17th with Leeds sitting just one point ahead of Leicester in the table. The Yorkshiremen have lost three in a row, though, while Leicester ended a nine-game run without a win at the weekend when they defeated Wolves. Prediction: Leeds 1 Leicester 2. Getty
WEDNESDAY - Nottingham Forest v Brighton (10.45pm): Forest have not won a game since February 5 and sit second bottom in the table. Brighton suffered penalty shoot-out heartache in their FA Cup semi-final defeat against Manchester United on Sunday but are still knocking on the door of the European places in the league. Prediciton: Forest 0 Brighton 2. PA
Chelsea v Brentford (10.45pm) Is fair to say the second coming of Frank Lampard as Chelsea manager has not gone as well as planned with the Blues having lost all four games since his return, albeit two of those were against European champions Real Madrid. They face a Brentford team without a win in six matches. Prediction: Chelsea 1 Brentford 1.
West Ham v Liverpool (10.45pm): West Ham have eased away from the relegation zone having taken seven points from a possible nine while also reaching the semi-final of the Europa Conference League. Liverpool have won their last two, scoring nine goals, but remain supsect defensively. Prediction: West Ham 2 Liverpool 2. AFP
Manchester City v Arsenal (11pm): Top-of-the-table clash at the Etihad Stadium with City looking to close the gap on Arsenal down to just two points, with Pep Gaurdiola's side enjoying two games in hand. The Gunners were swept aside 3-1 at the Emirates in February and could well be looking at a similar deficit here. Prediction: City 4 Arsenal 2. EPA
THURSDAY - Everton v Newcastle (10.45pm): The Magpies will be flying after their stunning 6-1 battering of Spurs on Sunday that saw Eddie Howe's team go 5-0 up within 21 minutes to give their top-four hopes a massive boost. Next up is third bottom Everton who have gone five games without a win. Prediction: Everton 0 Newcastle 2. EPA
Southampton v Bournemouth (10.45pm): Bournemouth saw their two-game winning run come crashing to a halt when they were thrashed 4-0 at home by West Ham, which leaves them five points above the drop zone. Bottom club Southampton came within two minutes of beating table-topping Arsenal, only to concede two late goals and have to settle for a draw. Prediction: Southampton 1 Bournemouth 0. Reuters
Tottenham v Manchester United (11pm): Crisis club Spurs are on to their third manager of the season with Ryan Mason now in temporary charge after the exits of Antonio Conte and Christian Stellini, the latter leaving a day after losing 6-1 at Newcastle. United are looking to make it four league wins on the trot after securing an FA Cup final spot last weekend. Prediction: Spurs 1 United 3. AP